Mankai® is a cultivated strain of Wolffia globosa an aquatic plant of the family Lemnaceae commonly known as Duckweeds. Recent studies suggest that consumption of a Mankai® enriched diet may provide positive health effects by decreasing body weight and improving glucose homeostasis and plasma lipid profiles. However, the effects of Mankai® alone on the composition and metabolic output of the human gut microbiota has not been fully investigated. Here, Mankai® was digested and fermented in vitro using a batch culture model of the proximal colon. Inulin and cellulose were used as readily and poorly fermentable control fibers respectively. Mankai® significantly stimulated the production of phenolic metabolites and short chain fatty acids by the gut microbiota (p<0.05). Three major microbial metabolites, 3-4-hydroxyphenyl propionic acid, 3-3-hydroxyphenyl propanoic acid and protocatechuic acid were significantly increased after 24 h fermentation. Moreover, Mankai® treatment lowered the overall microbial diversity (p<0.05), in line with a selective microbiome modulation.

Diotallevi, C.; Gaudioso, G.; Fava, F.; Angeli, A.; Lotti, C.; Vrhovsek, U.; Rinott, E.; Shai, I.; Gobbetti, M.; Tuohy, K. (2021). Measuring the effect of Mankai® (Wolffia globosa) on the gut microbiota and its metabolic output using an in vitro colon model. JOURNAL OF FUNCTIONAL FOODS, 84: 104597. doi: 10.1016/j.jff.2021.104597 handle: http://hdl.handle.net/10449/71936

Measuring the effect of Mankai® (Wolffia globosa) on the gut microbiota and its metabolic output using an in vitro colon model

Diotallevi, Camilla
Primo
;
Gaudioso, Giulia;Fava, Francesca;Angeli, Andrea;Lotti, Cesare;Vrhovsek, Urska;Tuohy, Kieran
Ultimo
2021-01-01

Abstract

Mankai® is a cultivated strain of Wolffia globosa an aquatic plant of the family Lemnaceae commonly known as Duckweeds. Recent studies suggest that consumption of a Mankai® enriched diet may provide positive health effects by decreasing body weight and improving glucose homeostasis and plasma lipid profiles. However, the effects of Mankai® alone on the composition and metabolic output of the human gut microbiota has not been fully investigated. Here, Mankai® was digested and fermented in vitro using a batch culture model of the proximal colon. Inulin and cellulose were used as readily and poorly fermentable control fibers respectively. Mankai® significantly stimulated the production of phenolic metabolites and short chain fatty acids by the gut microbiota (p<0.05). Three major microbial metabolites, 3-4-hydroxyphenyl propionic acid, 3-3-hydroxyphenyl propanoic acid and protocatechuic acid were significantly increased after 24 h fermentation. Moreover, Mankai® treatment lowered the overall microbial diversity (p<0.05), in line with a selective microbiome modulation.
Mankai®
Wolffia globosa
Polyphenols
Microbiota
Batch culture
Short chain fatty acids
Settore AGR/15 - SCIENZE E TECNOLOGIE ALIMENTARI
2021
Diotallevi, C.; Gaudioso, G.; Fava, F.; Angeli, A.; Lotti, C.; Vrhovsek, U.; Rinott, E.; Shai, I.; Gobbetti, M.; Tuohy, K. (2021). Measuring the effect of Mankai® (Wolffia globosa) on the gut microbiota and its metabolic output using an in vitro colon model. JOURNAL OF FUNCTIONAL FOODS, 84: 104597. doi: 10.1016/j.jff.2021.104597 handle: http://hdl.handle.net/10449/71936
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