CINECA IRIS Institutional Research Information System

Discovery of new broad-spectrum anti-infectives for eukaryotic pathogens using bioorganometallic chemistry

Drug resistance observed with many anti-infectives clearly highlights the need for new broad-spectrum agents to treat especially neglected tropical diseases (NTDs)caused by eukaryotic parasitic pathogens, including fungal infections. Herein, we show that the simple modification of one of the most well-known antifungal drugs, fluconazole, with organometallic moieties not only improves the activity of the parent drug but also broadens the scope of application of the new derivatives. These compo...

The Brazilian grapevine variety called ‘Peverella’ corresponds to the ‘Boschera’ variety

Through fingerprinting analysis using reference microsatellite markers and comparing with the Vitis International Variety Catalogue (VIVC) database, it was possible to discover that in Brazil, the wine grape variety cultivated for over 70 years, called 'Peverella' (Variety number VIVC = 12963; National Register of Vine Varieties (Italy), code: 254) is actually the grape variety called 'Boschera' (Variety number VIVC = 1576; National Register of Vine Varieties (Italy), code: 326). This discove...

A multi-indicator approach to compare the sustainability of organic vs. integrated management of grape production

Sustainable agricultural practices are increasingly becoming a strategic asset for global and national environmental policies and economy. A big challenge is the selection of appropriate indicators to describe the complexity of the agroecosystem management. In the present work, the sustainability of grape production, in vineyard trials of Pinot blanc and Rhine Riesling, managed with integrated (INT) and organic management (organic, with cattle manure ORG1 and organic with green manure ORG2), ...

Melo in conversione a biologico, valutazioni vegeto-produttive