Cannabidiol (CBD) is a non-psychoactive cannabinoid of Cannabis sativa that exhibits several beneficial pharmacological effects, including anti-inflammatory and antioxidant properties. The molecule can be obtained via extraction from the plant or through a biosynthetic route. The two products have both advantages and disadvantages, thus necessitating the development of methods capable of distinguishing between the two products. In this study, for the first time, the analysis of the stable isotope ratios of oxygen and hydrogen demonstrated high efficiency in the discrimination of CBD of a totally natural origin from that obtained through chemical synthesis. Considering a probability level of 95%, it was possible to identify threshold values for δ2H and δ18O of the totally natural CBD of −215‰ and +23.4‰, respectively. Higher values may indicate a non-entirely natural origin of CBD (i.e., a biosynthetic molecule).

Perini, M.; Gaggiotti, A.; Pianezze, S.; Ziller, L.; Larcher, R. (2023). Stable Isotope Ratio Analysis for authentication of natural antioxidant cannabidiol (CBD) from Cannabis sativa. ANTIOXIDANTS, 12 (7): 1421. doi: 10.3390/antiox12071421 handle: https://hdl.handle.net/10449/80815

Stable Isotope Ratio Analysis for authentication of natural antioxidant cannabidiol (CBD) from Cannabis sativa

Perini, Matteo
Primo
;
Pianezze, Silvia
;
Ziller, Luca;Larcher, Roberto
Ultimo
2023-01-01

Abstract

Cannabidiol (CBD) is a non-psychoactive cannabinoid of Cannabis sativa that exhibits several beneficial pharmacological effects, including anti-inflammatory and antioxidant properties. The molecule can be obtained via extraction from the plant or through a biosynthetic route. The two products have both advantages and disadvantages, thus necessitating the development of methods capable of distinguishing between the two products. In this study, for the first time, the analysis of the stable isotope ratios of oxygen and hydrogen demonstrated high efficiency in the discrimination of CBD of a totally natural origin from that obtained through chemical synthesis. Considering a probability level of 95%, it was possible to identify threshold values for δ2H and δ18O of the totally natural CBD of −215‰ and +23.4‰, respectively. Higher values may indicate a non-entirely natural origin of CBD (i.e., a biosynthetic molecule).
Cannabidiol
Cannabis sativa L
Stable Isotope Ratio Analysis
Biosynthetic
Authentication
Settore CHIM/10 - CHIMICA DEGLI ALIMENTI
2023
Perini, M.; Gaggiotti, A.; Pianezze, S.; Ziller, L.; Larcher, R. (2023). Stable Isotope Ratio Analysis for authentication of natural antioxidant cannabidiol (CBD) from Cannabis sativa. ANTIOXIDANTS, 12 (7): 1421. doi: 10.3390/antiox12071421 handle: https://hdl.handle.net/10449/80815
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