An accurate analysis of the composition of stable isotopes is today an increasingly important requirement in various fields of science (from the environmental to the medical field). Since 2004, the year of its introduction on the market, Liquid Chromatography coupled with Isotope Ratio Mass Spectrometry (LC-IRMS) has expanded the applications possible with the most famous and widespread Elemental Analyzer (EA) and Gas Chromatography Combustion (GC-C)-IRMS techniques. The new liquid chromatography interface coupled with IRMS opened to new application areas, in particular by enabling compound-specific δ13C analysis of non-volatile, water-soluble compounds from complex mixtures. The advantages of the technique include the possibility of performing a compound-specific analysis without altering isotopic signatures by derivatization. Applications in paleoarchaeology, nutrition and trophic, pediatrics, soil science and food authenticity are examined here by reporting on the progress and technical constraints.

Perini, M.; Bontempo, L. (2022). Liquid Chromatography coupled to Isotope Ratio Mass Spectrometry (LC-IRMS): a review. TRAC. TRENDS IN ANALYTICAL CHEMISTRY, 147: 116515. doi: 10.1016/j.trac.2021.116515 handle: http://hdl.handle.net/10449/68895

Liquid Chromatography coupled to Isotope Ratio Mass Spectrometry (LC-IRMS): a review

Perini, M.
Primo
;
Bontempo, L.
Ultimo
2022-01-01

Abstract

An accurate analysis of the composition of stable isotopes is today an increasingly important requirement in various fields of science (from the environmental to the medical field). Since 2004, the year of its introduction on the market, Liquid Chromatography coupled with Isotope Ratio Mass Spectrometry (LC-IRMS) has expanded the applications possible with the most famous and widespread Elemental Analyzer (EA) and Gas Chromatography Combustion (GC-C)-IRMS techniques. The new liquid chromatography interface coupled with IRMS opened to new application areas, in particular by enabling compound-specific δ13C analysis of non-volatile, water-soluble compounds from complex mixtures. The advantages of the technique include the possibility of performing a compound-specific analysis without altering isotopic signatures by derivatization. Applications in paleoarchaeology, nutrition and trophic, pediatrics, soil science and food authenticity are examined here by reporting on the progress and technical constraints.
Stable Isotope Ratio Analysis
High-Performance Liquid Chromatography
Paleo archaeology
Nutrition
Trophic
Pediatrics
Soil science
Food authenticity
Settore CHIM/10 - CHIMICA DEGLI ALIMENTI
2022
Perini, M.; Bontempo, L. (2022). Liquid Chromatography coupled to Isotope Ratio Mass Spectrometry (LC-IRMS): a review. TRAC. TRENDS IN ANALYTICAL CHEMISTRY, 147: 116515. doi: 10.1016/j.trac.2021.116515 handle: http://hdl.handle.net/10449/68895
File in questo prodotto:
File Dimensione Formato  
2022 TAC Perini et al.pdf

solo utenti autorizzati

Tipologia: Versione editoriale (Publisher’s layout)
Licenza: Tutti i diritti riservati (All rights reserved)
Dimensione 687.46 kB
Formato Adobe PDF
687.46 kB Adobe PDF   Visualizza/Apri   Richiedi una copia

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10449/68895
Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus 13
  • ???jsp.display-item.citation.isi??? 9
social impact