The gut:brain axis is emerging as an important information highway linking the foods we eat with neurophysiological development and functions. Some gut microorganisms have shown to alleviate anxiety and depression, improve cognitive performance and play a role in brain development in early life. However, most studies were conducted in laboratory animals and these findings await confirmation in carefully designed human interventions. Similarly, little attention has been given to how diet:microbe interactions within the gut can impact on neurotransmitter production or their subsequent biological effects within the nervous system. In this review, we discuss the possible influence of carbohydrates, polyphenols, lipids and proteins colonic fermentation on production, bioavailability and biological activity of metabolites linked to the gut-microbiota-brain axis. An increased understanding of how nervous system may be regulated by diet will greatly enhance our ability to design dietary strategies to improve healthy brain development and functions.

Ceppa, F.; Mancini, A.; Tuohy, K. (2019). Current evidence linking diet to gut microbiota and brain development and function. INTERNATIONAL JOURNAL OF FOOD SCIENCES AND NUTRITION, 70 (1): 1-19. doi: 10.1080/09637486.2018.1462309 handle: http://hdl.handle.net/10449/49410

Current evidence linking diet to gut microbiota and brain development and function

Ceppa, F.
Primo
;
Mancini, A.;Tuohy, K.
Ultimo
2019-01-01

Abstract

The gut:brain axis is emerging as an important information highway linking the foods we eat with neurophysiological development and functions. Some gut microorganisms have shown to alleviate anxiety and depression, improve cognitive performance and play a role in brain development in early life. However, most studies were conducted in laboratory animals and these findings await confirmation in carefully designed human interventions. Similarly, little attention has been given to how diet:microbe interactions within the gut can impact on neurotransmitter production or their subsequent biological effects within the nervous system. In this review, we discuss the possible influence of carbohydrates, polyphenols, lipids and proteins colonic fermentation on production, bioavailability and biological activity of metabolites linked to the gut-microbiota-brain axis. An increased understanding of how nervous system may be regulated by diet will greatly enhance our ability to design dietary strategies to improve healthy brain development and functions.
Microbial fermentation
Diet–microbe interactions
Gut-brain axis
Macronutrients metabolism
Neuroactive compounds
Tryptophan metabolism
Settore BIO/19 - MICROBIOLOGIA GENERALE
2019
Ceppa, F.; Mancini, A.; Tuohy, K. (2019). Current evidence linking diet to gut microbiota and brain development and function. INTERNATIONAL JOURNAL OF FOOD SCIENCES AND NUTRITION, 70 (1): 1-19. doi: 10.1080/09637486.2018.1462309 handle: http://hdl.handle.net/10449/49410
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10449/49410
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