The contents of stilbene monomers, cis-resveratrol, trans-resveratrol, cis-piceid, trans-piceid, and tyrosol, were quantified in Vitis vinifera red wines, cvs. Cabernet Franc, Merlot, Sangiovese, and Syrah, 2006 and 2007 vintages, from the So Joaquim region, a new grape-growing region at southern Brazil. Moreover, the effect of chronic consumption of these wines on the antioxidant and hypolipidemic activities was monitored in C57BL6 LDL receptor knockout mice and treated with a hypercholesterolemic diet. Red wines from this region had substantial levels of resveratrols (the predominant forms were glycoside and trans) and tyrosol. Biomonitoring of antioxidant and hypolipidemic activities in vivo revealed that consumption of these wines increased the antioxidant capacity and reduced the hypercholesterolemia and hypertriglyceridemia promoted by the hypercholesterolemic diet. Significant correlations were found between the increase of antioxidant capacity markers, the decrease of lipid levels promoted by wine consumption, and the contents of stilbenes and tyrosol, supporting the important biological activity of these compounds.

Fortes Gris, E.; Mattivi, F.; Ferreira, E.A.; Vrhovsek, U.; Filho, D.W.; Curi Pedrosa, R.; Bordignon Luiz, M.T. (2011). Stilbenes and tyrosol as target compounds in the assessment of antioxidant and hypolipidemic activity of Vitis vinifera red wines from Southern Brazil. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 59 (14): 7954-7961. doi: 10.1021/jf2008056 handle: http://hdl.handle.net/10449/20241

Stilbenes and tyrosol as target compounds in the assessment of antioxidant and hypolipidemic activity of Vitis vinifera red wines from Southern Brazil

Mattivi, Fulvio;Vrhovsek, Urska;
2011-01-01

Abstract

The contents of stilbene monomers, cis-resveratrol, trans-resveratrol, cis-piceid, trans-piceid, and tyrosol, were quantified in Vitis vinifera red wines, cvs. Cabernet Franc, Merlot, Sangiovese, and Syrah, 2006 and 2007 vintages, from the So Joaquim region, a new grape-growing region at southern Brazil. Moreover, the effect of chronic consumption of these wines on the antioxidant and hypolipidemic activities was monitored in C57BL6 LDL receptor knockout mice and treated with a hypercholesterolemic diet. Red wines from this region had substantial levels of resveratrols (the predominant forms were glycoside and trans) and tyrosol. Biomonitoring of antioxidant and hypolipidemic activities in vivo revealed that consumption of these wines increased the antioxidant capacity and reduced the hypercholesterolemia and hypertriglyceridemia promoted by the hypercholesterolemic diet. Significant correlations were found between the increase of antioxidant capacity markers, the decrease of lipid levels promoted by wine consumption, and the contents of stilbenes and tyrosol, supporting the important biological activity of these compounds.
Vitis vinifera red wines
Stilbenes
Tyrosol
Antioxidant activity
Hypolipidemic activity
2011
Fortes Gris, E.; Mattivi, F.; Ferreira, E.A.; Vrhovsek, U.; Filho, D.W.; Curi Pedrosa, R.; Bordignon Luiz, M.T. (2011). Stilbenes and tyrosol as target compounds in the assessment of antioxidant and hypolipidemic activity of Vitis vinifera red wines from Southern Brazil. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 59 (14): 7954-7961. doi: 10.1021/jf2008056 handle: http://hdl.handle.net/10449/20241
File in questo prodotto:
File Dimensione Formato  
2011 JAFC Mattivi et al.pdf

non disponibili

Licenza: Tutti i diritti riservati (All rights reserved)
Dimensione 991.07 kB
Formato Adobe PDF
991.07 kB Adobe PDF   Visualizza/Apri   Richiedi una copia

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10449/20241
Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus 52
  • ???jsp.display-item.citation.isi??? 47
social impact