In physiological conditions, the response to oxidative stress induced by strenuous physical training, is not always efficient. Furthermore, a weak muscle fiber antioxidant system can contribute to muscle wasting during ageing and pathological conditions. Natural antioxidant supplements could counteract the effects of oxidative stress. An in vitro model of exercise allowed us to mimic intense or moderate exercise by electrically stimulating cultured mouse myotubes with high- and/or low-frequency pulses; the resulting ROS production was then monitored. The herbal supplement Rhodiola rosea aqueous extract was characterized in terms of its polyphenol content and used to test for antioxidant activity against ROS, produced during muscle contraction. Our results showed that Rhodiola rosea extract reduced the oxidative stress produced by muscle contraction and brought values of ROS production back to physiological levels. We suggest that Rhodiola rosea root extract could exert a protective antioxidant role during intense physical exercise.

Sist, P.; Tramer, F.; Lorenzon, P.; Urbani, R.; Vrhovsek, U.; Bernareggi, A.; Sciancalepore, M. (2018). Rhodiola rosea, a protective antioxidant for intense physical exercise: an in vitro study. JOURNAL OF FUNCTIONAL FOODS, 48: 27-36. doi: 10.1016/j.jff.2018.06.022 handle: http://hdl.handle.net/10449/51478

Rhodiola rosea, a protective antioxidant for intense physical exercise: an in vitro study

Vrhovsek, U.;
2018-01-01

Abstract

In physiological conditions, the response to oxidative stress induced by strenuous physical training, is not always efficient. Furthermore, a weak muscle fiber antioxidant system can contribute to muscle wasting during ageing and pathological conditions. Natural antioxidant supplements could counteract the effects of oxidative stress. An in vitro model of exercise allowed us to mimic intense or moderate exercise by electrically stimulating cultured mouse myotubes with high- and/or low-frequency pulses; the resulting ROS production was then monitored. The herbal supplement Rhodiola rosea aqueous extract was characterized in terms of its polyphenol content and used to test for antioxidant activity against ROS, produced during muscle contraction. Our results showed that Rhodiola rosea extract reduced the oxidative stress produced by muscle contraction and brought values of ROS production back to physiological levels. We suggest that Rhodiola rosea root extract could exert a protective antioxidant role during intense physical exercise.
Rhodiola rosea
Mouse myotubes
Skeletal muscle
Physical exercise
Reactive oxygen species
Settore CHIM/10 - CHIMICA DEGLI ALIMENTI
2018
Sist, P.; Tramer, F.; Lorenzon, P.; Urbani, R.; Vrhovsek, U.; Bernareggi, A.; Sciancalepore, M. (2018). Rhodiola rosea, a protective antioxidant for intense physical exercise: an in vitro study. JOURNAL OF FUNCTIONAL FOODS, 48: 27-36. doi: 10.1016/j.jff.2018.06.022 handle: http://hdl.handle.net/10449/51478
File in questo prodotto:
File Dimensione Formato  
Sist et al_JFunctional food_2018.pdf

solo utenti autorizzati

Licenza: Tutti i diritti riservati (All rights reserved)
Dimensione 925.84 kB
Formato Adobe PDF
925.84 kB Adobe PDF   Visualizza/Apri   Richiedi una copia

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10449/51478
Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus 8
  • ???jsp.display-item.citation.isi??? 7
social impact