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ItalianoPrebiotics, probiotics and synbiotics are dietary ingredients with the potential to influence health and mucosal and systemic immune function by altering the composition of the gut microbiota. In the present study, a candidate prebiotic (xylo-oligosaccharide, XOS, 8 g/d), probiotic (Bifidobacterium animalis subsp. lactis Bi-07, 109 colony-forming units (CFU)/d) or synbiotic (8 g XOS+109 CFU Bi-07/d) was given to healthy adults (25-65 years) for 21 d. The aim was to identify the effect of the supplements on bowel habits, self-reported mood, composition of the gut microbiota, blood lipid concentrations and immune function. XOS supplementation increased mean bowel movements per d (P= 0·009), but did not alter the symptoms of bloating, abdominal pain or flatulence or the incidence of any reported adverse events compared with maltodextrin supplementation. XOS supplementation significantly increased participant-reported vitality (P= 0·003) and happiness (P= 0·034). Lowest reported use of analgesics was observed during the XOS+Bi-07 supplementation period (P= 0·004). XOS supplementation significantly increased faecal bifidobacterial counts (P= 0·008) and fasting plasma HDL concentrations (P= 0·005). Bi-07 supplementation significantly increased faecal B. lactis content (P= 0·007), lowered lipopolysaccharide-stimulated IL-4 secretion in whole-blood cultures (P= 0·035) and salivary IgA content (P= 0·040) and increased IL-6 secretion (P= 0·009). XOS supplementation resulted in lower expression of CD16/56 on natural killer T cells (P= 0·027) and lower IL-10 secretion (P= 0·049), while XOS and Bi-07 supplementation reduced the expression of CD19 on B cells (XOS × Bi-07, P= 0·009). The present study demonstrates that XOS induce bifidogenesis, improve aspects of the plasma lipid profile and modulate the markers of immune function in healthy adults. The provision of XOS+Bi-07 as a synbiotic may confer further benefits due to the discrete effects of Bi-07 on the gut microbiota and markers of immune function
| Citation: | Childs, C.; Röytiö, H.; Alhoniemi, E.; Fekete, A.A.; Forssten, S.; Hudjec, N.; Lim, Y.N.; Steger, C.J.; Yaqoob, P.; Tuohy, K.M.; Rastall, R.A.; Ouwehand, A.C.; Gibson, G.R. (2014). Xylo-oligosaccharides alone or in synbiotic combination with Bifidobacterium animalis subsp. lactis induce bifidogenesis andmodulate markers of immune function in healthy adults: a double-blind,placebo-controlled, randomised, factorial cross-over study. BRITISH JOURNAL OF NUTRITION, 111 (11): 1945-1956. doi: 10.1017/S0007114513004261 handle: http://hdl.handle.net/10449/23911 |
| Internal authors: | |
| Organization unit: | Food Quality and Nutrition Department # CRI_2011-JAN2016 |
| Authors: | Childs, C.; Röytiö, H.; Alhoniemi, E.; Fekete, A.A.; Forssten, S.; Hudjec, N.; Lim, Y.N.; Steger, C.J.; Yaqoob, P.; Tuohy, K.M.; Rastall, R.A.; Ouwehand, A.C.; Gibson, G.R. |
| Title: | Xylo-oligosaccharides alone or in synbiotic combination with Bifidobacterium animalis subsp. lactis induce bifidogenesis and modulate markers of immune function in healthy adults: a double-blind, placebo-controlled, randomised, factorial cross-over study |
| Journal: | BRITISH JOURNAL OF NUTRITION |
| Issue Date: | 2014 |
| Scientific Disciplinary Area: | Settore BIO/19 - Microbiologia Generale |
| Keywords ENG: | Pre-, pro- and synbiotics Gut microbiota Immune function |
| Keywords ITA: | Immunologia |
| Language: | English |
| IF: | With Impact Factor ISI |
| Publication status: | Published |
| Nature of content: | Articolo in rivista/Article |
| Digital Object Identifier (DOI): | http://dx.doi.org/10.1017/S0007114513004261 |
| Appears in Collections: | 01 - Journal article |
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| File | Description | Type | License | |
|---|---|---|---|---|
| 2014 BJN Childs et al.pdf | N/A | Tutti i diritti riservati (All rights reserved) | Embargo Request a copy |
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