Ecological determinants driving orthohantavirus prevalence in small mammals of Europe: a systematic review

Orthohantaviruses are emerging zoonotic pathogens that cause severe human disease and are considered an emerging public health threat globally. Mammalian orthohantaviruses are naturally maintained in rodent species and occasionally in other mammals. The abundance and density of natural orthohantavirus reservoir species are affected by multi annual and seasonal population cycles, community composition, ecosystem variables and climate. Horizontal transmission between host species is mostly density-driven and occurs via contact with infected host excreta, thus, fluctuations in populations and environmental variables often determine the prevalence of hantavirus in natural hosts. Given the zoonotic potential of hantaviruses, ecological factors influencing their spread and persistence in their natural reservoir and population dynamics influencing horizontal transmission require critical evaluation for human infection risk assessment. The present review paper discusses the impacts of natural host population cycles and ecosystem diversity, environmental conditions, and abiotic factors on the epidemiology of rodent-borne hantavirus infections in Europe. While significant efforts have been made to understand the drivers of hantavirus prevalence in natural hosts, we highlight key challenges in evaluating viral prevalence and assessing the role of environmental and population variables in determining hantavirus prevalence in host species