It is unclear whether West Nile virus (WNV) circulates between Africa and Europe, despite numerous studies supporting an African origin and high transmission in Europe. We integrated genomic data with geographic observations and phylogenetic and phylogeographic inferences to uncover the spatial and temporal viral dynamics of WNV between these two continents. We focused our analysis towards WNV lineages 1 (L1) and 2 (L2), the most spatially widespread and pathogenic WNV lineages. Our study shows a Northern-Western African origin of L1, with back-and-forth exchanges between West Africa and Southern-Western Europe; and a Southern African origin of L2, with one main introduction from South Africa to Europe, and no back introductions observed. We also noticed a potential overlap between L1 and L2 Eastern and Western phylogeography and two Afro-Palearctic bird migratory flyways. Future studies linking avian and mosquito species susceptibility, migratory connectivity patterns, and phylogeographic inference are suggested to elucidate the dynamics of emerging viruses

Mencattelli, G.; Ndione, M.H.D.; Silverj, A.; Diagne, M.M.; Curini, V.; Teodori, L.; Di Domenico, M.; Mbaye, R.; Leone, A.; Marcacci, M.; Gaye, A.; Ndiaye, E.; Diallo, D.; Ancora, M.; Secondini, B.; Di Lollo, V.; Mangone, I.; Bucciacchio, A.; Polci, A.; Marini, G.; Rosa', R.; Segata, N.; Fall, G.; Cammà, C.; Monaco, F.; Diallo, M.; Rota-Stabelli, O.; Faye, O.; Rizzoli, A.; Savini, G. (2023-10-13). Spatial and temporal dynamics of West Nile virus between Africa and Europe. NATURE COMMUNICATIONS, 14 (1): 6440. doi: 10.1038/s41467-023-42185-7 handle: https://hdl.handle.net/10449/82455

Spatial and temporal dynamics of West Nile virus between Africa and Europe

Mencattelli, Giulia
Primo
;
Silverj, Andrea;Marini, Giovanni;Rosa', Roberto;Rota-Stabelli, Omar;Rizzoli, Annapaola;
2023-10-13

Abstract

It is unclear whether West Nile virus (WNV) circulates between Africa and Europe, despite numerous studies supporting an African origin and high transmission in Europe. We integrated genomic data with geographic observations and phylogenetic and phylogeographic inferences to uncover the spatial and temporal viral dynamics of WNV between these two continents. We focused our analysis towards WNV lineages 1 (L1) and 2 (L2), the most spatially widespread and pathogenic WNV lineages. Our study shows a Northern-Western African origin of L1, with back-and-forth exchanges between West Africa and Southern-Western Europe; and a Southern African origin of L2, with one main introduction from South Africa to Europe, and no back introductions observed. We also noticed a potential overlap between L1 and L2 Eastern and Western phylogeography and two Afro-Palearctic bird migratory flyways. Future studies linking avian and mosquito species susceptibility, migratory connectivity patterns, and phylogeographic inference are suggested to elucidate the dynamics of emerging viruses
Settore BIO/07 - ECOLOGIA
13-ott-2023
Mencattelli, G.; Ndione, M.H.D.; Silverj, A.; Diagne, M.M.; Curini, V.; Teodori, L.; Di Domenico, M.; Mbaye, R.; Leone, A.; Marcacci, M.; Gaye, A.; Ndiaye, E.; Diallo, D.; Ancora, M.; Secondini, B.; Di Lollo, V.; Mangone, I.; Bucciacchio, A.; Polci, A.; Marini, G.; Rosa', R.; Segata, N.; Fall, G.; Cammà, C.; Monaco, F.; Diallo, M.; Rota-Stabelli, O.; Faye, O.; Rizzoli, A.; Savini, G. (2023-10-13). Spatial and temporal dynamics of West Nile virus between Africa and Europe. NATURE COMMUNICATIONS, 14 (1): 6440. doi: 10.1038/s41467-023-42185-7 handle: https://hdl.handle.net/10449/82455
File in questo prodotto:
File Dimensione Formato  
2023 NC Mencattelli.pdf

accesso aperto

Tipologia: Versione editoriale (Publisher’s layout)
Licenza: Creative commons
Dimensione 9.65 MB
Formato Adobe PDF
9.65 MB Adobe PDF Visualizza/Apri

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10449/82455
Citazioni
  • ???jsp.display-item.citation.pmc??? 3
  • Scopus 6
  • ???jsp.display-item.citation.isi??? 6
social impact