CINECA IRIS Institutional Research Information System
IRIS is the IT solution to facilitate the collection and management of data and activities related to research product.
ItalianoA novel test is described that visualizes the absolute model-data fit of the substitution and tree components of an evolutionary model. The test utilizes statistics based on counts of character state matches and mismatches in alignments of observed and simulated sequences. This comparison is used to assess model-data fit. In simulations conducted to evaluate the performance of the test, the test estimator was able to identify both the correct tree topology and substitution model under conditions where the Goldman–Cox test—which tests the fit of a substitution model to sequence data and is also based on comparing simulated replicates with observed data—showed high error rates. The novel test was found to identify the correct tree topology within a wide range of DNA substitution model misspecifications, indicating the high discriminatory power of the test. Use of this test provides a practical approach for assessing absolute model-data fit when testing phylogenetic hypotheses.
| Citation: | Goremykin, V. (2019). A novel test for absolute fit of evolutionary models provides a means to correctly identify the substitution model and the model tree. GENOME BIOLOGY AND EVOLUTION, 11 (8): 2403-2419. doi: 10.1093/gbe/evz167 handle: http://hdl.handle.net/10449/58626 |
| Internal authors: | Goremykin, Vadim (Corresponding) |
| Organization unit: | Computational Biology # CRI_2011-JAN2016 |
| Authors: | Goremykin, V. |
| Title: | A novel test for absolute fit of evolutionary models provides a means to correctly identify the substitution model and the model tree |
| Journal: | GENOME BIOLOGY AND EVOLUTION |
| Issue Date: | 2019 |
| Scientific Disciplinary Area: | Settore BIO/11 - Biologia Molecolare |
| Keywords ENG: | Molecular evolution Phylogenetics Model-data fit Evolutionary models |
| Language: | English |
| IF: | With Impact Factor ISI |
| Publication status: | Published |
| Nature of content: | Articolo in rivista/Article |
| Digital Object Identifier (DOI): | http://dx.doi.org/10.1093/gbe/evz167 |
| Appears in Collections: | 01 - Journal article |
Files in This Item:
| File | Description | Type | License | |
|---|---|---|---|---|
| evz167(1).pdf | Versione editoriale (Publisher’s layout) |  | Open AccessView/Open |
Copyright © 2020