Failure to effectively prove cause and effect between taking probiotics and improvements in recognised markers of disease has greatly hindered the acceptability of probiotic health claims. • One reason for this may be poor probiotic selection. Probiotic strains have not always been selected on the basis of specific health related mechanisms. • Examples of probiotics first selected for bile salt hydrolase activities or gamma-aminobutyric acid (GABA) production are proving exceptions however, and are showing that rational design of probiotic strains capable of modulating host physiological function is possible. • This presentation will discuss the merits of probiotic reverse engineering, selecting probiotic strains with very specific phenotypes capable altering target mammalian physiological processes.
Tuohy, K.M. (2017). Probiotic reverse engineering: choose your mechanism first then your strain. In: 4th Microbiome R&D and Business collaboration Forum, Amsterdam, April 3-4, 2017. handle: http://hdl.handle.net/10449/46186
Probiotic reverse engineering: choose your mechanism first then your strain
Tuohy, K. M.
2017-01-01
Abstract
Failure to effectively prove cause and effect between taking probiotics and improvements in recognised markers of disease has greatly hindered the acceptability of probiotic health claims. • One reason for this may be poor probiotic selection. Probiotic strains have not always been selected on the basis of specific health related mechanisms. • Examples of probiotics first selected for bile salt hydrolase activities or gamma-aminobutyric acid (GABA) production are proving exceptions however, and are showing that rational design of probiotic strains capable of modulating host physiological function is possible. • This presentation will discuss the merits of probiotic reverse engineering, selecting probiotic strains with very specific phenotypes capable altering target mammalian physiological processes.File | Dimensione | Formato | |
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Amsterdam conference April 3 2017 MRAD17-PBC17_Agenda.pdf
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