The first natural chromosomal variation in the house mouse was described nearly 50 years ago in Val Poschiavo on the Swiss side of the Swiss–Italian border in the Central Eastern Alps. Studies have extended into neighboring Valtellina, and the house mice of the Poschiavo-Valtellina area have been subject to detailed analysis, reviewed here. The maximum extent of this area is 70 km, yet it has 4 metacentric races and the standard 40-chromosome telocentric race distributed in a patchwork fashion. The metacentric races are characterized by highly reduced diploid numbers (2n  =  22–26) resulting from Robertsonian fusions, perhaps modified by whole-arm reciprocal translocations. The races hybridize and the whole Poschiavo-Valtellina area can be considered a “hybrid zone.” The studies of this area have provided insights into origin of races within hybrid zones, gene flow within hybrid zones and the possibility of speciation in hybrid zones. This provides a case study of how chromosomal rearrangements may impact the genetic structure of populations and their diversification.

Giménez, M.D.; Förster, D.W.; Jones, E.P.; Jóhannesdóttir, F.; Gabriel, S.I.; Panithanarak, T.; Scascitelli, M.; Merico, V.; Garagna, S.; Searle, J.B.; Hauffe, H.C. (2017). A half-century of studies on a chromosomal hybrid zone of the house mouse. JOURNAL OF HEREDITY, 108 (1): 25-35. doi: 10.1093/jhered/esw061 handle: http://hdl.handle.net/10449/34056

A half-century of studies on a chromosomal hybrid zone of the house mouse

Hauffe, Heidi Christine
Ultimo
2017-01-01

Abstract

The first natural chromosomal variation in the house mouse was described nearly 50 years ago in Val Poschiavo on the Swiss side of the Swiss–Italian border in the Central Eastern Alps. Studies have extended into neighboring Valtellina, and the house mice of the Poschiavo-Valtellina area have been subject to detailed analysis, reviewed here. The maximum extent of this area is 70 km, yet it has 4 metacentric races and the standard 40-chromosome telocentric race distributed in a patchwork fashion. The metacentric races are characterized by highly reduced diploid numbers (2n  =  22–26) resulting from Robertsonian fusions, perhaps modified by whole-arm reciprocal translocations. The races hybridize and the whole Poschiavo-Valtellina area can be considered a “hybrid zone.” The studies of this area have provided insights into origin of races within hybrid zones, gene flow within hybrid zones and the possibility of speciation in hybrid zones. This provides a case study of how chromosomal rearrangements may impact the genetic structure of populations and their diversification.
Chromosomal evolution
Mus musculus domesticus
Robertsonian fusion
Speciation
Zonal raciation
Evoluzione
Mus musculus domesticus
Fusione Robertsoniana
Speciazione
Razze robertsoniane
Settore BIO/05 - ZOOLOGIA
2017
Giménez, M.D.; Förster, D.W.; Jones, E.P.; Jóhannesdóttir, F.; Gabriel, S.I.; Panithanarak, T.; Scascitelli, M.; Merico, V.; Garagna, S.; Searle, J.B.; Hauffe, H.C. (2017). A half-century of studies on a chromosomal hybrid zone of the house mouse. JOURNAL OF HEREDITY, 108 (1): 25-35. doi: 10.1093/jhered/esw061 handle: http://hdl.handle.net/10449/34056
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10449/34056
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