Localizing genes that are subject to recent positive selection is a major goal of evolutionary biology. In the model organism Drosophila melanogaster many attempts have been made in recent years to identify such genes by conducting so-called genome scans of selection. These analyses consisted in typing a large number of genetic markers along the genomes of a sample of individuals and then identifying those loci that harbor patterns of genetic variation, which are compatible with the ones generated by a selective sweep. In this study we conduct an in-depth analysis of a genomic region located on the X chromosome of D. melanogaster that was identified as a potential target of recent positive selection by a previous genome scan of selection. To this end we re-sequenced 20 kilobases around the Flotillin-2 gene (Flo-2) and conducted a detailed analysis of the allele frequencies and linkage disequilibria observed in this new dataset. The results of this analysis reveal eight genetic novelties that are specific to temperate populations of D. melanogaster and that may have arisen during the expansion of the species outside its ancestral sub-Saharan habitat since about 16,000 years ago.

Werzner, A.; Pavlidis, P.; Ometto, L.; Stephan, W.; Laurent, S. (2013). Selective sweep in the Flotillin-2 region of European Drosophila melanogaster. PLOS ONE, 8 (2): e56629. doi: 10.1371/journal.pone.0056629 handle: http://hdl.handle.net/10449/33236

Selective sweep in the Flotillin-2 region of European Drosophila melanogaster

Ometto, Lino;
2013-01-01

Abstract

Localizing genes that are subject to recent positive selection is a major goal of evolutionary biology. In the model organism Drosophila melanogaster many attempts have been made in recent years to identify such genes by conducting so-called genome scans of selection. These analyses consisted in typing a large number of genetic markers along the genomes of a sample of individuals and then identifying those loci that harbor patterns of genetic variation, which are compatible with the ones generated by a selective sweep. In this study we conduct an in-depth analysis of a genomic region located on the X chromosome of D. melanogaster that was identified as a potential target of recent positive selection by a previous genome scan of selection. To this end we re-sequenced 20 kilobases around the Flotillin-2 gene (Flo-2) and conducted a detailed analysis of the allele frequencies and linkage disequilibria observed in this new dataset. The results of this analysis reveal eight genetic novelties that are specific to temperate populations of D. melanogaster and that may have arisen during the expansion of the species outside its ancestral sub-Saharan habitat since about 16,000 years ago.
Population genetics
Genetica di popolazione
Settore BIO/05 - ZOOLOGIA
2013
Werzner, A.; Pavlidis, P.; Ometto, L.; Stephan, W.; Laurent, S. (2013). Selective sweep in the Flotillin-2 region of European Drosophila melanogaster. PLOS ONE, 8 (2): e56629. doi: 10.1371/journal.pone.0056629 handle: http://hdl.handle.net/10449/33236
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10449/33236
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