Candida albicans is an ubiquitous fungal commensal of human skin and mucosal surfaces, and at the same time a major life-threatening human fungal pathogen in immunocompromised individuals. Host defense mechanisms rely on the capacity of professional phagocytes to recognize Candida cell wall antigens. During the past decade, the host immune response to Candida was dissected in depth, highlighting the essential role of C-type lectin receptors, especially regarding the power of the Dectins' family in discriminating between the tolerated yeast-like form of Candida and its invading counterpart, the hyphae. This review focuses on the immuno-modulatory properties of the Candida morphologies and their specific interactions with the host innate immune system in different body surfaces.

Rizzetto, L.; Weil, T.F.A.L.; Cavalieri, D. (2015). Systems level dissection of Candida recognition by dectins: a matter of fungal morphology and site of infection. PATHOGENS, 4 (3): 639-661. doi: 10.3390/pathogens4030639 handle: http://hdl.handle.net/10449/26483

Systems level dissection of Candida recognition by dectins: a matter of fungal morphology and site of infection

Rizzetto, Lisa;Weil, Tobias Franz Anton Ludwig;Cavalieri, Duccio
2015-01-01

Abstract

Candida albicans is an ubiquitous fungal commensal of human skin and mucosal surfaces, and at the same time a major life-threatening human fungal pathogen in immunocompromised individuals. Host defense mechanisms rely on the capacity of professional phagocytes to recognize Candida cell wall antigens. During the past decade, the host immune response to Candida was dissected in depth, highlighting the essential role of C-type lectin receptors, especially regarding the power of the Dectins' family in discriminating between the tolerated yeast-like form of Candida and its invading counterpart, the hyphae. This review focuses on the immuno-modulatory properties of the Candida morphologies and their specific interactions with the host innate immune system in different body surfaces.
C-type lectin receptors
Candida albicans
Innate immunity
Morphology
Pathogen
Yeast-hyphae
Settore BIO/19 - MICROBIOLOGIA GENERALE
2015
Rizzetto, L.; Weil, T.F.A.L.; Cavalieri, D. (2015). Systems level dissection of Candida recognition by dectins: a matter of fungal morphology and site of infection. PATHOGENS, 4 (3): 639-661. doi: 10.3390/pathogens4030639 handle: http://hdl.handle.net/10449/26483
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10449/26483
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