Survey technologies, such as metabolomics and proteomics, play increasingly important roles in the investigation of complex biological systems. These methods produce data sets that typically provide a huge amount of information using relatively few samples, so that finding differences between two groups, a fairly common question in this context, runs the risk of leading to many false positives. Often, the comparison is made on several thousand experimental variables, and strategies to correct for multiple-testing issues are necessary

Franceschi, P.; Giordan, M.; Wehrens, H.R.M.J. (2013). Multiple comparisons in mass-spectrometry-based -omics technologies. TRAC. TRENDS IN ANALYTICAL CHEMISTRY, 50 (1): 11-21. doi: 10.1016/j.trac.2013.04.011 handle: http://hdl.handle.net/10449/22675

Multiple comparisons in mass-spectrometry-based -omics technologies

Franceschi, Pietro;Giordan, Marco;Wehrens, Herman Ronald Maria Johan
2013-01-01

Abstract

Survey technologies, such as metabolomics and proteomics, play increasingly important roles in the investigation of complex biological systems. These methods produce data sets that typically provide a huge amount of information using relatively few samples, so that finding differences between two groups, a fairly common question in this context, runs the risk of leading to many false positives. Often, the comparison is made on several thousand experimental variables, and strategies to correct for multiple-testing issues are necessary
Biological system
Chemometrics
Mass spectrometry
Metabolomics
Multiple comparisons
Multiple testing
Omics
Proteomics
Set-based approach
Statistical tool
Metabolomica
Confronti multipli
Analisi dati
Settore CHIM/01 - CHIMICA ANALITICA
2013
Franceschi, P.; Giordan, M.; Wehrens, H.R.M.J. (2013). Multiple comparisons in mass-spectrometry-based -omics technologies. TRAC. TRENDS IN ANALYTICAL CHEMISTRY, 50 (1): 11-21. doi: 10.1016/j.trac.2013.04.011 handle: http://hdl.handle.net/10449/22675
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10449/22675
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