Host: microbiome co-metabolic processing of dietary polyphenols – a cross-over study with different doses of apple polyphenols in healthy subjects

Human metabolism of apple polyphenols is a co-metabolic process between human encoded activities and those of our resident microbiota. We are delighted to show nutrikinetics study where the aim was to effectively identify the metabolic products of various classes of apple polyphenols using an untargeted metabolomics. We assessed whether particular profiles of apple derived plasma/urine metabolites could be related to individual members of the gut microbiota. Finally we evaluated whether an higher concentration of polyphenols in the apple matrix, would lead to a corresponding increased metabolic output.