The immune system is essential to maintain the mutualistic homeostatic interaction between the host and its micro- and mycobiota. Living as a commensal on human skin and mucosa and being a passenger in the digestive tract, Saccharomyces cerevisiae could potentially modulate the host immunity and significantly shape the immune response. We observed that diverse S. cerevisiae strains train monocytes in a strain-dependent manner leading to enhanced cytokine production upon in vitro stimulation with TLR ligands and bacterial commensals. These features are reflected by the differences in the pro-inflammatory properties dependent on the origin of the strains, which may be potentially related to the different adaptation to the environment from which they were isolated. We established that even though β-glucan is sufficient to train the innate immunity, S. cerevisiae chitin drives the induction of trained immunity potentiatiang cytokine modulation and killing ability. Differential chitin content accounts also for the differences in training properties observed among strains, being the clinical strains the most suited to that. This study reveals how commensal and passenger microorganisms could be important in promoting health and preventing mucosal diseases by modulating host defense and regulating the microbiota. Dietary supplementation of foodborne microorganisms appears a viable strategy to train a healthy immune system. This work was supported by funding from the European Community’s Integrative Project FP7, SYBARIS (Grant Agreement 242220, www.sybaris.eu) and by funding from Provincia Autonoma di Trento’s Accordo di Programma (METAFOODLABS project)
Rizzetto, L.; Ifrim, C.I.; Tocci, N.; Cheng, S.C.; Quintin, J.; De Filippo, C.; Santos, M.A.S.; Netea, M.G.; Cavalieri, D. (2015). S. cerevisiae chitin drives trained immunity during cross-talk with microbiota. In: Innate Immune Memory, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK, March 18-20, 2015. url: https://registration.hinxton.wellcome.ac.uk/display_info.asp?id=469 handle: http://hdl.handle.net/10449/25081
S. cerevisiae chitin drives trained immunity during cross-talk with microbiota
Rizzetto, Lisa;Tocci, Noemi;De Filippo, Carlotta;Cavalieri, Duccio
2015-01-01
Abstract
The immune system is essential to maintain the mutualistic homeostatic interaction between the host and its micro- and mycobiota. Living as a commensal on human skin and mucosa and being a passenger in the digestive tract, Saccharomyces cerevisiae could potentially modulate the host immunity and significantly shape the immune response. We observed that diverse S. cerevisiae strains train monocytes in a strain-dependent manner leading to enhanced cytokine production upon in vitro stimulation with TLR ligands and bacterial commensals. These features are reflected by the differences in the pro-inflammatory properties dependent on the origin of the strains, which may be potentially related to the different adaptation to the environment from which they were isolated. We established that even though β-glucan is sufficient to train the innate immunity, S. cerevisiae chitin drives the induction of trained immunity potentiatiang cytokine modulation and killing ability. Differential chitin content accounts also for the differences in training properties observed among strains, being the clinical strains the most suited to that. This study reveals how commensal and passenger microorganisms could be important in promoting health and preventing mucosal diseases by modulating host defense and regulating the microbiota. Dietary supplementation of foodborne microorganisms appears a viable strategy to train a healthy immune system. This work was supported by funding from the European Community’s Integrative Project FP7, SYBARIS (Grant Agreement 242220, www.sybaris.eu) and by funding from Provincia Autonoma di Trento’s Accordo di Programma (METAFOODLABS project)
I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
