The construction of a network of cell-to-cell contacts makes it possible to characterize the patterns and spatial organisation of tissues. Such networks are highly dynamic, depending on the changes of the tissue architecture caused by cell division, death and migration. Local competitive and cooperative cell-to-cell interactions influence the choices cells make. We review the literature on quantitative data of epithelial tissue topology and present a dynamical network model that can be used to explore the evolutionary dynamics of a two dimensional tissue architecture with arbitrary cell-to-cell interactions. In particular, we show that various forms of experimentally observed types of interactions can be modelled using game theory. We discuss a model of cooperative and non-cooperative cell-to-cell communication that can capture the interplay between cellular competition and tissue dynamics. We conclude with an outlook on the possible uses of this approach in modelling tumorigenesis and tissue homeostasis
Csikasz Nagy, A. (2014). Epithelial topology dynamics in tissue homeostasis and tumorigenesis. In: Interdisciplinary Signaling Workshop, 21-25 July 2014, Visegrád, Hungary: 34. url: http://signalingworkshop.org/ handle: http://hdl.handle.net/10449/24808
Epithelial topology dynamics in tissue homeostasis and tumorigenesis
Csikasz Nagy, Attila
2014-01-01
Abstract
The construction of a network of cell-to-cell contacts makes it possible to characterize the patterns and spatial organisation of tissues. Such networks are highly dynamic, depending on the changes of the tissue architecture caused by cell division, death and migration. Local competitive and cooperative cell-to-cell interactions influence the choices cells make. We review the literature on quantitative data of epithelial tissue topology and present a dynamical network model that can be used to explore the evolutionary dynamics of a two dimensional tissue architecture with arbitrary cell-to-cell interactions. In particular, we show that various forms of experimentally observed types of interactions can be modelled using game theory. We discuss a model of cooperative and non-cooperative cell-to-cell communication that can capture the interplay between cellular competition and tissue dynamics. We conclude with an outlook on the possible uses of this approach in modelling tumorigenesis and tissue homeostasisFile | Dimensione | Formato | |
---|---|---|---|
Signaling Workshop - Program and Abstracts.pdf
non disponibili
Descrizione: Abstract book
Licenza:
Tutti i diritti riservati (All rights reserved)
Dimensione
4.59 MB
Formato
Adobe PDF
|
4.59 MB | Adobe PDF | Visualizza/Apri Richiedi una copia |
I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.