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EnglishThe constant improvement of high-throughput technologies has led to a great increase in generated data per single experiment. Pathway analysis is a widespread method to understand experimental results at the system level. Pathway Processor 2.0 is an upgrade over the original Pathway Processor program developed in 2002, extended to support more species, analysis methods, and RNAseq data in addition to microarrays through a simple Web-based interface. The tool can perform two different types of analysis: the first covers the traditional Fisher's Test used by Pathway Processor and topology-aware analyses, which take into account the propagation of changes over the whole structure of a pathway, and the second is a new pathway-based method to investigate differences between phenotypes of interest. Common problems and troubleshooting are also discussed
Beltrame, L.; Bianco, L.; Fontana, P.; Cavalieri, D. (2013). Pathway-based analysis of microarray and RNAseq data using pathway processor 2.0. In: Current protocols in bioinformatics (editor(s) Baxevanis, A.D.). Oxford: Wiley: 7.6.1-7.6.12. ISBN: 9780471250951 doi: 10.1002/0471250953.bi0706s41. handle: http://hdl.handle.net/10449/21933
| Citation: | Beltrame, L.; Bianco, L.; Fontana, P.; Cavalieri, D. (2013). Pathway-based analysis of microarray and RNAseq data using pathway processor 2.0. In: Current protocols in bioinformatics (editor(s) Baxevanis, A.D.). Oxford: Wiley: 7.6.1-7.6.12. ISBN: 9780471250951 doi: 10.1002/0471250953.bi0706s41. handle: http://hdl.handle.net/10449/21933 |
| Internal authors: | |
| Organization unit: | Computational Biology # CRI_2011-JAN2016 |
| Authors: | Beltrame, L.; Bianco, L.; Fontana, P.; Cavalieri, D. |
| Title: | Pathway-based analysis of microarray and RNAseq data using pathway processor 2.0 |
| Scientific Disciplinary Area: | Settore BIO/18 - Genetica |
| Keywords ENG: | Biological pathways Gene expression analysis Web tool |
| Book editors: | Baxevanis, A.D. |
| Book title: | Current protocols in bioinformatics |
| Publisher name: | Wiley |
| Issue Date: | 2013 |
| ISBN: | 9780471250951 |
| Nature of content: | Contributo in volume (Capitolo o Saggio)/Book chapter (Chapter or Essay) |
| Digital Object Identifier (DOI): | http://dx.doi.org/10.1002/0471250953.bi0706s41 |
| Appears in Collections: | 02 - Book chapter |
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