Due to the spreading and increasing drug resistance of pathogens, the search for novel antibiotics is becoming ever more important. Plant-derived polyphenols are a vast and promising class of compounds with a potential to fight infectious diseases. Still, they are not routinely used in clinical practice. No reports on the in vivo studies of these compounds have been presented. The aim of our work was to compare the antimicrobial activity of resveratrol (stilbene), dihydroquercetin and dihydromyricetin (flavonols) extracted from the bark and wood of conifers against the dermatophytes Staphylococcus aureus, Pseudomonas aeruginosa and Candida albicans. Using the radial diffusion assay, we established that dihydroquercetin, resveratrol and dihydromyricetin exhibit high activity against S. aureus even at the smallest possible concentrations of 0.22, 0.15, and 0.15 mM, respectively. In contrast, the highest achievable concentrations of these compounds in the solutions (21.5, 15.5 and 15.0 mM for dihydroquercetin, resveratrol and dihydromyricetin, respectively) have no effect on the growth of P. aeruginosa and C. albicans. These findings suggest that polyphenols derived from conifers could have a potential to be used as a medicine for topical application to treat bacterial infections of the skin caused by S. aureus.

Shevelev, A.B.; Isakova, E.P.; Trubnikova, E.V.; La Porta, N.; Martens, S.; Medvedev, O.A.; Trubnikov, D.V.; Akbaev, R.M.; Biryukova, Y.K.; Zylkova, M.V.; Lebedeva, A.A.; Smirnova1, M.S.; Deryabina, Y.I. (2018). A study of antimicrobial activity of polyphenols derived from wood.. BULLETIN OF RUSSIAN STATE MEDICAL UNIVERSITY, 7 (4): 46-49. doi: 10.24075/brsmu.2018.040 handle: http://hdl.handle.net/10449/52284

A study of antimicrobial activity of polyphenols derived from wood.

La Porta N.;Martens S.;
2018-01-01

Abstract

Due to the spreading and increasing drug resistance of pathogens, the search for novel antibiotics is becoming ever more important. Plant-derived polyphenols are a vast and promising class of compounds with a potential to fight infectious diseases. Still, they are not routinely used in clinical practice. No reports on the in vivo studies of these compounds have been presented. The aim of our work was to compare the antimicrobial activity of resveratrol (stilbene), dihydroquercetin and dihydromyricetin (flavonols) extracted from the bark and wood of conifers against the dermatophytes Staphylococcus aureus, Pseudomonas aeruginosa and Candida albicans. Using the radial diffusion assay, we established that dihydroquercetin, resveratrol and dihydromyricetin exhibit high activity against S. aureus even at the smallest possible concentrations of 0.22, 0.15, and 0.15 mM, respectively. In contrast, the highest achievable concentrations of these compounds in the solutions (21.5, 15.5 and 15.0 mM for dihydroquercetin, resveratrol and dihydromyricetin, respectively) have no effect on the growth of P. aeruginosa and C. albicans. These findings suggest that polyphenols derived from conifers could have a potential to be used as a medicine for topical application to treat bacterial infections of the skin caused by S. aureus.
Polyphenols
Flavonoid
Stilbene
Antimicrobial agents
Resveratrol
Antimicrobial activity
Antioxidants
Wood
Settore BIO/03 - BOTANICA AMBIENTALE E APPLICATA
2018
Shevelev, A.B.; Isakova, E.P.; Trubnikova, E.V.; La Porta, N.; Martens, S.; Medvedev, O.A.; Trubnikov, D.V.; Akbaev, R.M.; Biryukova, Y.K.; Zylkova, M.V.; Lebedeva, A.A.; Smirnova1, M.S.; Deryabina, Y.I. (2018). A study of antimicrobial activity of polyphenols derived from wood.. BULLETIN OF RUSSIAN STATE MEDICAL UNIVERSITY, 7 (4): 46-49. doi: 10.24075/brsmu.2018.040 handle: http://hdl.handle.net/10449/52284
File in questo prodotto:
File Dimensione Formato  
2018 Shevelev et al - Bul RSMU - Wood Polyphenols.pdf

accesso aperto

Licenza: Creative commons
Dimensione 148.4 kB
Formato Adobe PDF
148.4 kB Adobe PDF Visualizza/Apri

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10449/52284
Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus 5
  • ???jsp.display-item.citation.isi??? 1
social impact